One change from Bolton win
Ben Elliott comes into the side after scoring his first Reading goal on Tuesday night in the only change from the side who started against Bolton Wanderers last Saturday.
Harvey Knibbs drops to the bench, and Lewis Wing returns to the bench after a period out due to injury.
This sees Academy graduates Nelson Abbey and Kelvin Ehibhatiomhan continue their run of games, as well as 18-year-old defender Tyler Bindon.
David Button searches for his third clean sheet of the season, whilst Andy Yiadom skippers the side.
Deadline day signings Clinton Mola and Dom Ballard both feature from the beginning. The latter picked up a brace in Tuesday's historic win, as did Paul Mukairu who is on the bench.
Charlie Savage and Sam Hutchinson continue their partnership in midfield, with Femi Azeez rounding out the starting eleven.
Blackpool: Grimshaw, Husband, Pennington, Norburn, Dale, Dougall, Rhodes, Virtue, Casey, Hamilton, Kouassi.
Subs: O'Donnell, Connolly, Dembele, Weir, Lavery, Ekpiteta, Carey.
Reading: Button, Mola, Elliott, Savage, Ballard, Azeez, Ehibhatiomhan, Yiadom ©, Hutchinson, Bindon, Abbey.
Subs: Boyce-Clarke, McIntyre, Knibbs, Mukairu, Mbengue, Wing, Vickers.
